Asymmetrical lateral ventricular enlargement in Parkinson’s disease
Identifieur interne : 000B62 ( Main/Exploration ); précédent : 000B61; suivant : 000B63Asymmetrical lateral ventricular enlargement in Parkinson’s disease
Auteurs : M. M. Lewis [États-Unis] ; A. B. Smith [États-Unis] ; M. Styner [États-Unis] ; H. Gu [États-Unis] ; R. Poole [États-Unis] ; H. Zhu [États-Unis] ; Y. Li [États-Unis] ; X. Barbero [États-Unis] ; S. Gouttard [États-Unis] ; M. J. Mckeown [Canada] ; R. B. Mailman [États-Unis] ; X. Huang [États-Unis]Source :
- European Journal of Neurology [ 1351-5101 ] ; 2009-04.
English descriptors
- KwdEn :
Abstract
Background: A recent case report suggested the presence of asymmetrical lateral ventricular enlargement associated with motor asymmetry in Parkinson’s disease (PD). The current study explored these associations further. Methods: Magnetic resonance imaging (3T) scans were obtained on 17 PD and 15 healthy control subjects at baseline and 12–43 months later. Baseline and longitudinal lateral ventricular volumetric changes were compared between contralateral and ipsilateral ventricles in PD subjects relative to symptom onset side and in controls relative to their dominant hand. Correlations between changes in ventricular volume and United Parkinson’s disease rating scale motor scores (UPDRS‐III) whilst on medication were determined. Results: The lateral ventricle contralateral to symptom onset side displayed a faster rate of enlargement compared to the ipsilateral (P = 0.004) in PD subjects, with no such asymmetry detected (P = 0.312) in controls. There was a positive correlation between ventricular enlargement and worsening motor function assessed by UPDRS‐III scores (r = 0.96, P < 0.001). Discussion: There is asymmetrical lateral ventricular enlargement that is associated with PD motor asymmetry and progression. Further studies are warranted to investigate the underlying mechanism(s), as well as the potential of using volumetric measurements as a marker for PD progression.
Url:
DOI: 10.1111/j.1468-1331.2008.02430.x
Affiliations:
- Canada, États-Unis
- Caroline du Nord, Pennsylvanie
- University Park (Pennsylvanie)
- Université d'État de Pennsylvanie
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Mckeown</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medicine (Neurology), Pacific Parkinson's Research Centre, University of British Columbia, Vancouver, BC</wicri:regionArea><wicri:noRegion>BC</wicri:noRegion></affiliation></author><author><name sortKey="Mailman, R B" sort="Mailman, R B" uniqKey="Mailman R" first="R. B." last="Mailman">R. B. Mailman</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Pennsylvania State University, Milton S. 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Hershey Medical Center, Hershey, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">University Park (Pennsylvanie)</settlement></placeName><orgName type="university">Université d'État de Pennsylvanie</orgName></affiliation><affiliation wicri:level="2"><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Neurology, University of North Carolina, Chapel Hill</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry, University of North Carolina, Chapel Hill, NC</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">European Journal of Neurology</title><idno type="ISSN">1351-5101</idno><idno type="eISSN">1468-1331</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2009-04">2009-04</date><biblScope unit="volume">16</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="475">475</biblScope><biblScope unit="page" to="481">481</biblScope></imprint><idno type="ISSN">1351-5101</idno></series><idno type="istex">4933E4CD9FC469DD7DFF3724DC1770AA2831C942</idno><idno type="DOI">10.1111/j.1468-1331.2008.02430.x</idno><idno type="ArticleID">ENE2430</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1351-5101</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson’s disease</term><term>lateral ventricular volume</term><term>motor asymmetry</term><term>semi‐automatic segmentation</term><term>structural magnetic resonance imaging</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: A recent case report suggested the presence of asymmetrical lateral ventricular enlargement associated with motor asymmetry in Parkinson’s disease (PD). The current study explored these associations further. Methods: Magnetic resonance imaging (3T) scans were obtained on 17 PD and 15 healthy control subjects at baseline and 12–43 months later. Baseline and longitudinal lateral ventricular volumetric changes were compared between contralateral and ipsilateral ventricles in PD subjects relative to symptom onset side and in controls relative to their dominant hand. Correlations between changes in ventricular volume and United Parkinson’s disease rating scale motor scores (UPDRS‐III) whilst on medication were determined. Results: The lateral ventricle contralateral to symptom onset side displayed a faster rate of enlargement compared to the ipsilateral (P = 0.004) in PD subjects, with no such asymmetry detected (P = 0.312) in controls. There was a positive correlation between ventricular enlargement and worsening motor function assessed by UPDRS‐III scores (r = 0.96, P < 0.001). Discussion: There is asymmetrical lateral ventricular enlargement that is associated with PD motor asymmetry and progression. Further studies are warranted to investigate the underlying mechanism(s), as well as the potential of using volumetric measurements as a marker for PD progression.</div></front></TEI><affiliations><list><country><li>Canada</li><li>États-Unis</li></country><region><li>Caroline du Nord</li><li>Pennsylvanie</li></region><settlement><li>University Park (Pennsylvanie)</li></settlement><orgName><li>Université d'État de Pennsylvanie</li></orgName></list><tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Lewis, M M" sort="Lewis, M M" uniqKey="Lewis M" first="M. M." last="Lewis">M. M. Lewis</name></region><name sortKey="Barbero, X" sort="Barbero, X" uniqKey="Barbero X" first="X." last="Barbero">X. Barbero</name><name sortKey="Gouttard, S" sort="Gouttard, S" uniqKey="Gouttard S" first="S." last="Gouttard">S. Gouttard</name><name sortKey="Gu, H" sort="Gu, H" uniqKey="Gu H" first="H." last="Gu">H. Gu</name><name sortKey="Huang, X" sort="Huang, X" uniqKey="Huang X" first="X." last="Huang">X. Huang</name><name sortKey="Huang, X" sort="Huang, X" uniqKey="Huang X" first="X." last="Huang">X. Huang</name><name sortKey="Huang, X" sort="Huang, X" uniqKey="Huang X" first="X." last="Huang">X. Huang</name><name sortKey="Lewis, M M" sort="Lewis, M M" uniqKey="Lewis M" first="M. M." last="Lewis">M. M. Lewis</name><name sortKey="Lewis, M M" sort="Lewis, M M" uniqKey="Lewis M" first="M. M." last="Lewis">M. M. Lewis</name><name sortKey="Li, Y" sort="Li, Y" uniqKey="Li Y" first="Y." last="Li">Y. Li</name><name sortKey="Mailman, R B" sort="Mailman, R B" uniqKey="Mailman R" first="R. B." last="Mailman">R. B. Mailman</name><name sortKey="Mailman, R B" sort="Mailman, R B" uniqKey="Mailman R" first="R. B." last="Mailman">R. B. Mailman</name><name sortKey="Mailman, R B" sort="Mailman, R B" uniqKey="Mailman R" first="R. B." last="Mailman">R. B. Mailman</name><name sortKey="Poole, R" sort="Poole, R" uniqKey="Poole R" first="R." last="Poole">R. Poole</name><name sortKey="Smith, A B" sort="Smith, A B" uniqKey="Smith A" first="A. B." last="Smith">A. B. Smith</name><name sortKey="Styner, M" sort="Styner, M" uniqKey="Styner M" first="M." last="Styner">M. Styner</name><name sortKey="Styner, M" sort="Styner, M" uniqKey="Styner M" first="M." last="Styner">M. Styner</name><name sortKey="Zhu, H" sort="Zhu, H" uniqKey="Zhu H" first="H." last="Zhu">H. Zhu</name></country><country name="Canada"><noRegion><name sortKey="Mckeown, M J" sort="Mckeown, M J" uniqKey="Mckeown M" first="M. J." last="Mckeown">M. J. Mckeown</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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